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Current evidence suggests that most patients regain significant weight within one year of stopping semaglutide, indicating that this is likely a long-term or indefinite therapy for obesity management rather than a short-term intervention

Genetic variants in carnitine-related genes (SLC22A5, CPT1, CPT2) can cause disorders that affect energy production, causing issues from mild fatigue to severe dysfunction

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At the final follow-up, these scores were reduced to 15, 18, and 16, in the same order